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Live birth rate was defined as the number of deliveries that resulted in a live born neonate, expressed per 100 embryo transfers (Zegers-Hochschild et al., 2009). The primary outcome was the birth of a live born neonate.

The total number of patients was 3262 and the number of cycles was 4367. Patients who used gestational carriers were not included in this study. This is a retrospective cohort study that included all patients who underwent fresh, non-donor intracytoplasmic sperm injection (ICSI) cycles and may have had subsequent fresh or frozen cycles at our unit between 20. Our objective is to provide information that can be used for counseling when discussing the impact of age and transfer day on live birth rate. We report the cumulative probability of live birth after 3 cycles based on female age and the day of embryo transfer.

If there is a limited number on day 3 though, our policy is to do the transfer on day 3. Our unit moved to day 5 transfers (whenever day 5 transfer is possible) approximately 11 years ago based on data showing higher implantation and delivery rates and fewer multiple pregnancies with day 5 transfers (ASRM Practice Committee Opinion, 2013). Although this article examined transfer day of the embryo and female age, it did not analyze these factors together (Luke et al., 2012).

Recently, an article examined the impact of several factors on live birth rates. Studies describe increased anxiety, lowered self-esteem, depression and marital problems after in-vitro fertilization (IVF) treatment especially if the couple remains childless (Olivius et al., 2002). This reflects the financial but also the physical and emotional strain of ART (Malizia et al., 2013).

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In France, where the first four cycles are free 60% of patients returned for further cycles after one failed attempt compared to 30% of patients in the United Kingdom (Engmann et al., 1999). Unfortunately, in many parts of the world and in many states in the United States, there is no insurance mandate to cover any cycles.

FET SUCCESS RATE CALCULATOR FULL

One of these was a large study focusing on Massachusetts because it is one of a few states in the Unites States that mandate full insurance coverage for ART (Stern et al., 2010). Although there have been a few studies that have examined cumulative live birth rate (Engmann et al., 1999 Stern et al., 2010), there is none to our knowledge that has focused on the impact of transfer day by age group. Thus from the patients’ perspective, the cumulative probability of live birth is more important (Malizia et al., 2013). However, when one ART cycle fails, couples often want to know what their chance is of having a live birth if they continue with ART treatment. Several studies on ART examine per cycle chance of pregnancy and delivery (Olivius et al., 2002). When these couples present for counseling, they want to know the chance of a live birth should they decide to go through the rigors of assisted reproductive technology (ART) (Olivius et al., 2002). Our findings may impact the counseling of couples considering IVF treatment.Īn important public health issue, it is estimated that between 9% and 14% of couples in the developed world have difficulty conceiving (Walschaerts M et al., 2012). For women 40 years and above, better results of CLBR are observed with Day 5 transfers. When analyzing the live births by age and group, there was a significant difference in the CLBR after 3 cycles with the women less than 35 years having the highest CLBR and the women 40 years or older having the lowest CLBR.Ĭonclusion: In women less than 35 years, excellent CLBR can be achieved irrespective of the transfer day. After 3 cycles, Group 1’s CLBR was 79% versus 66% in Group 2. Results: The mean age for Group 1 was significantly lower than for Group 2. Using Kaplan-Meier analysis, we estimated the cumulative live birth rates for each group and according to female age. Cycles were analyzed until the first live birth or the end of the 3rd cycle. Patients who underwent both were excluded. Patients were divided into two groups Group 1 represented those who underwent only Day 5 transfers, Group 2 represented only Day 3 transfers. Materials and Methods: This study includes patients who underwent fresh, frozen and non-donor ICSI cycles at our IVF unit between 2006-2012. From a patients’ perspective, the cumulative probability of live birth is more informative. However, after a cycle fails, couples often want to know what their chances are of having a live birth if they continue treatment. Background: Many studies on assisted reproductive technology examine live birth rate per cycle.

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